DegronMD - Q9H5J0(ZBTB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D266G	TCGA-AP-A1DK	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.D266G	DO42033	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.S286Y	TCGA-AX-A2HC	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.0556
p.S286Y	DO41572	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.0556
p.V267D	TCGA-BS-A0UL	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.V267D	DO41319	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.A460S	TCGA-DK-A1AC	BLCA	TCGA	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.2222
p.A460S	DO514	BLCA	ICGC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.2222
p.F284L	TCGA-EY-A1GD	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.F284L	DO42129	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.E469K	TCGA-G2-AA3C	BLCA	TCGA	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation altering degron motif	0.7022
p.E469K	DO51883	BLCA	ICGC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation altering degron motif	0.7022
p.E456K	TCGA-VS-A958	CESC	TCGA	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.1111
p.E456K	DO51639	CESC	ICGC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.1111
p.V264M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.V264M	ACH-000981	Leukemia	CCLE	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.V264M	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.S455F	SIDM00884	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455F	ACH-000699	Breast Cancer	CCLE	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455F	HCC1395	breast	COSMIC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455A	SIDM00773	Non-Cancerous	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455A	SIDM00875	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455A	SIDM00774	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.S455A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.0833
p.E458K	SIDM00528	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.1667
p.E458K	ACH-000934	Breast Cancer	CCLE	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.1667
p.E458K	MDA-MB-361	breast	COSMIC	FGVFTE	LIG_APCC_ABBA_1	464:469	Mutation rewiring degron network	0.1667
p.P272S	SIDM01412	Oral Cavity Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.P272S	ACH-000762	Head and Neck Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.E277D	SIDM01611	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056
p.E277D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB3

UniProt ID: Q9H5J0

Entrez ID:

Protein name: Zinc finger and BTB domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB3 in