DegronMD

Uniprot ID: Q9H5J0

Source protein: Zinc finger and BTB domain-containing protein 3

Source gene: ZBTB3

Class: LIG_APCC_ABBA_1

Location: 464:469

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8309

ASA_SCORE: 77.0167

COIL: 0.7322

CONS_SCORE: 0.6508

DSS_SCORE: 0.1857

HELIX: 0.1087

FCONS_SCORE: 0.8845

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A460S	TCGA-DK-A1AC	BLCA	TCGA	FGVFTE	LIG_APCC_ABBA_1	0.2222
p.A460S	DO514	BLCA	ICGC	FGVFTE	LIG_APCC_ABBA_1	0.2222
p.E469K	TCGA-G2-AA3C	BLCA	TCGA	FGVFTE	LIG_APCC_ABBA_1	0.7022
p.E469K	DO51883	BLCA	ICGC	FGVFTE	LIG_APCC_ABBA_1	0.7022
p.E456K	TCGA-VS-A958	CESC	TCGA	FGVFTE	LIG_APCC_ABBA_1	0.1111
p.E456K	DO51639	CESC	ICGC	FGVFTE	LIG_APCC_ABBA_1	0.1111
p.S455F	SIDM00884	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455F	ACH-000699	Breast Cancer	CCLE	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455F	HCC1395	breast	COSMIC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455A	SIDM00773	Non-Cancerous	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455A	SIDM00875	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455A	SIDM00774	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.S455A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.0833
p.E458K	SIDM00528	Breast Carcinoma	GDSC	FGVFTE	LIG_APCC_ABBA_1	0.1667
p.E458K	ACH-000934	Breast Cancer	CCLE	FGVFTE	LIG_APCC_ABBA_1	0.1667
p.E458K	MDA-MB-361	breast	COSMIC	FGVFTE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5J0	Zinc finger and BTB domain-containing protein 3	LIG_APCC_ABBA_1	464:469	FGVFTE	APC,CDC20,FZR1	0.8309	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons