DegronMD - Q13495(MAMLD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P331Q	TCGA-17-Z055	LUAD	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.2778
p.H322N	TCGA-2H-A9GL	ESCA	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.2778
p.P334L	TCGA-34-8454	LUSC	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P334L	DO50094	LUSC	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P265H	TCGA-A5-A0G2	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.P265H	DO41235	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.P319S	TCGA-A5-A0G9	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P319S	TCGA-BK-A0C9	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P319S	DO42304	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P319S	DO41253	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.A267T	TCGA-AP-A1DV	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.A267T	DO50584	BOCA	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.A267T	DO224668	COCA	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.A267T	DO233737	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.A267T	DO43186	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.G234W	TCGA-AX-A2HD	UCEC	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.0556
p.G234W	DO42608	UCEC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.0556
p.R316L	TCGA-BR-6452	STAD	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1111
p.R316L	DO38404	STAD	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1111
p.P321S	TCGA-BS-A0UV	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.25
p.P321S	DO42793	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.25
p.P321T	TCGA-CR-7388	HNSC	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.25
p.P321T	DO14284	HNSC	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.25
p.A209V	TCGA-D8-A146	BRCA	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.1111
p.A209V	DO5984	BRCA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.1111
p.K244T	TCGA-E6-A1LX	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.K244T	DO41020	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.P249L	TCGA-G4-6588	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.P249L	DO10140	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.P249L	SIDM01753	Gastric Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.P249L	ACH-000239	Gastric Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.P334R	TCGA-HT-7877	LGG	TCGA	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.P334R	DO22634	LGG	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.1944
p.G234E	TCGA-W3-AA1V	SKCM	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.0556
p.G234E	DO51276	SKCM	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.0556
p.D213Y	DO10276	COAD	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.2222
p.D213Y	DO52412	UCEC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.2222
p.Y315H	DO228935	COCA	ICGC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.0833
p.L208M	DO228879	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.0833
p.G211V	DO229019	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.1667
p.A209S	DO229028	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.1111
p.L226I	DO45305	LIRI	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.2778
p.E213K	DO231047	LUSC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	217:224	Mutation rewiring degron network	0.2222
p.P314L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation substituting flanking lysine	0.1667
p.P314L	ACH-000960	Leukemia	CCLE	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation substituting flanking lysine	0.1667
p.P314L	REH	haematopoietic and lymphoid tissue	COSMIC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation substituting flanking lysine	0.1667
p.M263L	SIDM00337	Melanoma	GDSC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.M263L	ACH-000450	Skin Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.M263L	MEL-HO	skin	COSMIC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.L268V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.L268V	ACH-000669	Lung Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.L268V	SW900	lung	COSMIC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.A262S	SIDM00901	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.2222
p.A262S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.2222
p.A262S	AN3-CA	endometrium	COSMIC	PSSST	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.2222
p.S258R	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.7427
p.P339L	REH	haematopoietic and lymphoid tissue	COSMIC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation rewiring degron network	0.0556
p.K320T	HCC2998	large intestine	COSMIC	PTPSWS	DEG_SCF_FBW7_1	324:329	Mutation substituting flanking lysine	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAMLD1

UniProt ID: Q13495

Entrez ID: 10046

Protein name: Mastermind-like domain-containing protein 1 (F18) (Protein CG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAMLD1 in