DegronMD

Uniprot ID: Q13495

Source protein: Mastermind-like domain-containing protein 1

Source gene: MAMLD1

Class: DEG_SCF_FBW7_1

Location: 217:224

E3 ligase: FBXW7

DEGRON score: 0.982

ASA_SCORE: 90.9

COIL: 0.9681

CONS_SCORE: 0.6915

DSS_SCORE: 0.5967

HELIX: 0.0189

FCONS_SCORE: 0.8593

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G234W	TCGA-AX-A2HD	UCEC	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	0.0556
p.G234W	DO42608	UCEC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.0556
p.A209V	TCGA-D8-A146	BRCA	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	0.1111
p.A209V	DO5984	BRCA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.1111
p.G234E	TCGA-W3-AA1V	SKCM	TCGA	LSTTPKPS	DEG_SCF_FBW7_1	0.0556
p.G234E	DO51276	SKCM	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.0556
p.D213Y	DO10276	COAD	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.2222
p.D213Y	DO52412	UCEC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.2222
p.L208M	DO228879	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.0833
p.G211V	DO229019	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.1667
p.A209S	DO229028	LICA	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.1111
p.L226I	DO45305	LIRI	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.2778
p.E213K	DO231047	LUSC	ICGC	LSTTPKPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13495	Mastermind-like domain-containing protein 1	DEG_SCF_FBW7_1	217:224	LSTTPKPS	FBXW7	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons