DegronMD

Uniprot ID: Q13495

Source protein: Mastermind-like domain-containing protein 1

Source gene: MAMLD1

Class: DEG_SCF_FBW7_1

Location: 324:329

E3 ligase: FBXW7

DEGRON score: 0.8542

ASA_SCORE: 94.2333

COIL: 0.9593

CONS_SCORE: 0.7223

DSS_SCORE: 0.757

HELIX: 0.022

FCONS_SCORE: 0.8824

RIG_SCORE: 0.5379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P331Q	TCGA-17-Z055	LUAD	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.2778
p.H322N	TCGA-2H-A9GL	ESCA	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.2778
p.P334L	TCGA-34-8454	LUSC	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P334L	DO50094	LUSC	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P319S	TCGA-A5-A0G9	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P319S	TCGA-BK-A0C9	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P319S	DO42304	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P319S	DO41253	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.R316L	TCGA-BR-6452	STAD	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.1111
p.R316L	DO38404	STAD	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.1111
p.P321S	TCGA-BS-A0UV	UCEC	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.25
p.P321S	DO42793	UCEC	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.25
p.P321T	TCGA-CR-7388	HNSC	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.25
p.P321T	DO14284	HNSC	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.25
p.P334R	TCGA-HT-7877	LGG	TCGA	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.P334R	DO22634	LGG	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.1944
p.Y315H	DO228935	COCA	ICGC	PTPSWS	DEG_SCF_FBW7_1	0.0833
p.P314L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PTPSWS	DEG_SCF_FBW7_1	0.1667
p.P314L	ACH-000960	Leukemia	CCLE	PTPSWS	DEG_SCF_FBW7_1	0.1667
p.P314L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSWS	DEG_SCF_FBW7_1	0.1667
p.P339L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSWS	DEG_SCF_FBW7_1	0.0556
p.K320T	HCC2998	large_intestine	COSMIC	PTPSWS	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13495	Mastermind-like domain-containing protein 1	DEG_SCF_FBW7_1	324:329	PTPSWS	FBXW7	0.8542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons