DegronMD - Q9P0K1(ADAM22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D787G	TCGA-AJ-A3EL	UCEC	TCGA	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6087
p.D787G	DO41542	UCEC	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6087
p.S866Y	TCGA-B5-A1MR	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S866Y	DO41758	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S866Y	SIDM00534	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S866Y	ACH-000986	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S866Y	HT-115	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.Q771H	TCGA-ER-A195	SKCM	TCGA	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.0833
p.Q771H	DO47712	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.0833
p.Q771H	SIDM01469	Pancreatic Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.0833
p.Q771H	ACH-000085	Pancreatic Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.0833
p.D780V	TCGA-HU-A4GF	STAD	TCGA	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.7785
p.D780V	DO47885	STAD	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.7785
p.R795Q	DO6308	CESC	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.1667
p.R795Q	DO37410	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.1667
p.T860N	DO222884	COCA	ICGC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation blocking phosphorylation signal	0.5833
p.K865N	DO228986	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2778
p.K865N	DO229038	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2778
p.G770V	DO229031	LICA	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.0556
p.P789S	DO219878	SKCA	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6752
p.S772Y	DO47623	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.1111
p.D781Y	DO42568	UCEC	ICGC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.7325
p.D782N	SIDM02068	Esophageal Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.5821
p.I788F	SIDM00845	Burkitt's Lymphoma	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	SIDM00461	Acute Myeloid Leukemia	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	SIDM01519	Head and Neck Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	ACH-000786	Lymphoma	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	ACH-000992	Head and Neck Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	ACH-001067	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	DND-41	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	Daudi	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.I788F	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.6304
p.S876A	SIDM00660	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.S876A	ACH-000985	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.S876A	LS-411N	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.S869T	SIDM00899	Pancreatic Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.7116
p.S869T	ACH-000222	Pancreatic Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.7116
p.S869T	AsPC-1	pancreas	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.7116
p.S783P	SIDM00567	Other Solid Cancers	GDSC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.5641
p.S783P	ACH-000776	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.5641
p.S783P	ONS-76	central nervous system	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.5641
p.A864D	SIDM00068	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.25
p.A864D	GEO	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.25
p.V792G	ACH-000786	Lymphoma	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.V792G	ACH-000992	Head and Neck Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.V792G	ACH-001067	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.V792G	DND-41	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.V792G	Daudi	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.V792G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.25
p.A875P	ACH-001538	Bile Duct Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.S862T	AsPC-1	pancreas	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.A857D	GEO	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation blocking phosphorylation signal	0.5
p.S774C	NCI-H1623	lung	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation rewiring degron network	0.1667
p.H784Y	SW620	large intestine	COSMIC	DGDSFYSDIP	CBL_PTK	780:789	Mutation altering degron motif	0.7229
p.S859Y	HT-115	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1111
p.S869A	LS-411N	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.87

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAM22

UniProt ID: Q9P0K1

Entrez ID: 53616

Protein name: Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAM22 in