DegronMD

Uniprot ID: Q9P0K1

Source protein: Disintegrin and metalloproteinase domain-containing protein 22

Source gene: ADAM22

Class: CBL_PTK

Location: 780:789

E3 ligase: CBL

DEGRON score: 0.9809

ASA_SCORE: 77.94

COIL: 0.8304

CONS_SCORE: 0.568

DSS_SCORE: 0.5753

HELIX: 0.052

FCONS_SCORE: 1.0363

RIG_SCORE: 0.6765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D787G	TCGA-AJ-A3EL	UCEC	TCGA	DGDSFYSDIP	CBL_PTK	0.6087
p.D787G	DO41542	UCEC	ICGC	DGDSFYSDIP	CBL_PTK	0.6087
p.Q771H	TCGA-ER-A195	SKCM	TCGA	DGDSFYSDIP	CBL_PTK	0.0833
p.Q771H	DO47712	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	0.0833
p.Q771H	SIDM01469	Pancreatic Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	0.0833
p.Q771H	ACH-000085	Pancreatic Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.0833
p.D780V	TCGA-HU-A4GF	STAD	TCGA	DGDSFYSDIP	CBL_PTK	0.7785
p.D780V	DO47885	STAD	ICGC	DGDSFYSDIP	CBL_PTK	0.7785
p.R795Q	DO6308	CESC	ICGC	DGDSFYSDIP	CBL_PTK	0.1667
p.R795Q	DO37410	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	0.1667
p.G770V	DO229031	LICA	ICGC	DGDSFYSDIP	CBL_PTK	0.0556
p.P789S	DO219878	SKCA	ICGC	DGDSFYSDIP	CBL_PTK	0.6752
p.S772Y	DO47623	SKCM	ICGC	DGDSFYSDIP	CBL_PTK	0.1111
p.D781Y	DO42568	UCEC	ICGC	DGDSFYSDIP	CBL_PTK	0.7325
p.D782N	SIDM02068	Esophageal Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	0.5821
p.I788F	SIDM00845	Burkitt's Lymphoma	GDSC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	SIDM00461	Acute Myeloid Leukemia	GDSC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	SIDM01519	Head and Neck Carcinoma	GDSC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	ACH-000786	Lymphoma	CCLE	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	ACH-000992	Head and Neck Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	ACH-001067	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.6304
p.I788F	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.6304
p.S783P	SIDM00567	Other Solid Cancers	GDSC	DGDSFYSDIP	CBL_PTK	0.5641
p.S783P	ACH-000776	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.5641
p.S783P	ONS-76	central_nervous_system	COSMIC	DGDSFYSDIP	CBL_PTK	0.5641
p.V792G	ACH-000786	Lymphoma	CCLE	DGDSFYSDIP	CBL_PTK	0.25
p.V792G	ACH-000992	Head and Neck Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.25
p.V792G	ACH-001067	Brain Cancer	CCLE	DGDSFYSDIP	CBL_PTK	0.25
p.V792G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.25
p.V792G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.25
p.V792G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSFYSDIP	CBL_PTK	0.25
p.S774C	NCI-H1623	lung	COSMIC	DGDSFYSDIP	CBL_PTK	0.1667
p.H784Y	SW620	large_intestine	COSMIC	DGDSFYSDIP	CBL_PTK	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGDSFYSDIP

Degron related mutations and impact score

Drug responses associated with ADAM22 mutations

All proteins holding degron of DGDSFYSDIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	CBL_PTK	780:789	DGDSFYSDIP	CBL	0.9809	More...