DegronMD - Q9Y463(DYRK1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I467F	TCGA-55-8510	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.2222
p.P452H	TCGA-EO-A22T	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1389
p.C458Y	TCGA-QK-A8Z7	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.G464D	DO233272	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.I469V	DO49659	LIHC	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667
p.P468T	DO23774	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1944
p.R456C	DO228322	MALY	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.25
p.R456C	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.25
p.P465S	DO220851	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.2778
p.S458R	DO219317	PRAD	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.S458I	DO52402	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.S462R	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.7427
p.A464T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.A464T	ACH-001498	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.A464T	Farage	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.R456H	SNU-175	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.25
p.C462Y	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.7087
p.C450Y	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.0833

Kaplan plot for DYRK1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYRK1B

UniProt ID: Q9Y463

Entrez ID: 9149

Protein name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DYRK1B in