DegronMD - Q9P278(FNIP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S257N	TCGA-44-3918	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.5958
p.S258C	TCGA-55-6979	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7541
p.S258C	DO24110	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7541
p.S259F	TCGA-55-A48Y	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7982
p.S259F	DO26160	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7982
p.R241P	TCGA-86-8673	LUAD	TCGA	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation altering degron motif	0.6401
p.D234H	TCGA-A8-A09M	BRCA	TCGA	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.2778
p.R268H	TCGA-AX-A1CE	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.1111
p.M226V	TCGA-B5-A3FA	UCEC	TCGA	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.0556
p.R241Q	TCGA-E6-A1LX	UCEC	TCGA	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation altering degron motif	0.6218
p.S107C	TCGA-VS-A9UP	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1944
p.D257H	DO3852	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7688
p.R236H	DO222790	COCA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation altering degron motif	0.8244
p.G261D	DO228627	GACA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.1667
p.G261D	DO228627	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.3056
p.S269I	DO49528	LAML	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.0833
p.C235Y	DO21053	LAML	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.3056
p.A242S	DO229015	LICA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation altering degron motif	0.7588
p.A242S	DO47578	SKCM	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation altering degron motif	0.7588
p.D257Y	DO229028	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7325
p.R264P	DO26260	LUAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.R264P	DO26260	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.2222
p.T103A	DO228253	MALY	ICGC	VSSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.P256L	DO222702	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation altering degron motif	0.7582
p.V247D	DO38567	STAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation blocking phosphorylation signal	0.75
p.V247D	DO38567	STAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation blocking phosphorylation signal	0.6389
p.V247D	DO38567	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation blocking phosphorylation signal	0.5278
p.G233S	DO51761	STAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.25
p.R264Q	DO41020	UCEC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.R264Q	DO41020	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.2222
p.M249V	DO52402	UCEC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.7208
p.S262C	SIDM00111	Glioma	GDSC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.1389
p.S262C	SIDM00111	Glioma	GDSC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.2778
p.S262C	U251	central nervous system	COSMIC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.1389
p.S262C	U251	central nervous system	COSMIC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.2778
p.R268C	SIDM01608	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.1111
p.S246N	SIDM01588	Endometrial Carcinoma	GDSC	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.2778
p.S246N	SIDM01588	Endometrial Carcinoma	GDSC	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.2222
p.S246N	SIDM01588	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.0556
p.S246N	ACH-000993	Endometrial/Uterine Cancer	CCLE	LLITPFPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.2778
p.S246N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGIARS	DEG_SCF_TRCP1_1	236:242	Mutation rewiring degron network	0.2222
p.S246N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	256:260	Mutation rewiring degron network	0.0556
p.S108P	ACH-001569	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	98:102	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for FNIP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FNIP2

UniProt ID: Q9P278

Entrez ID: 57600

Protein name: Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FNIP2 in