DegronMD

Uniprot ID: Q9P278

Source protein: Folliculin-interacting protein 2

Source gene: FNIP2

Class: DEG_SCF_FBW7_1

Location: 248:255

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 67.9625

COIL: 0.8294

CONS_SCORE: 0.3324

DSS_SCORE: 0.5046

HELIX: 0.0694

FCONS_SCORE: 0.7704

RIG_SCORE: 0.6655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G261D	DO228627	GACA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.1667
p.R264P	DO26260	LUAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.0833
p.V247D	DO38567	STAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.75
p.R264Q	DO41020	UCEC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.0833
p.M249V	DO52402	UCEC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7208
p.S262C	SIDM00111	Glioma	GDSC	LLITPFPS	DEG_SCF_FBW7_1	0.1389
p.S262C	U251	central_nervous_system	COSMIC	LLITPFPS	DEG_SCF_FBW7_1	0.1389
p.S246N	SIDM01588	Endometrial Carcinoma	GDSC	LLITPFPS	DEG_SCF_FBW7_1	0.2778
p.S246N	ACH-000993	Endometrial/Uterine Cancer	CCLE	LLITPFPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	DEG_SCF_FBW7_1	265:272	LLITPFPS	FBXW7	0.9976	More...
Q9P278	Folliculin-interacting protein 2	DEG_SCF_FBW7_1	248:255	LLITPFPS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons