DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: DEG_SCF_FBW7_1

Location: 265:272

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 68.275

COIL: 0.856

CONS_SCORE: 0.3919

DSS_SCORE: 0.4295

HELIX: 0.0535

FCONS_SCORE: 0.956

RIG_SCORE: 0.696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F270C	TCGA-AX-A0J0	UCEC	TCGA	LLITPFPS	DEG_SCF_FBW7_1	0.5996
p.F270C	SIDM01123	Prostate Carcinoma	GDSC	LLITPFPS	DEG_SCF_FBW7_1	0.5996
p.F270C	NCI-H660	prostate	COSMIC	LLITPFPS	DEG_SCF_FBW7_1	0.5996
p.S276A	TCGA-BR-8361	STAD	TCGA	LLITPFPS	DEG_SCF_FBW7_1	0.2222
p.L265S	TCGA-EB-A5UM	SKCM	TCGA	LLITPFPS	DEG_SCF_FBW7_1	0.7667
p.R263C	DO9490	COAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.R263C	DO36463	READ	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.R263C	DO41235	UCEC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.R263H	DO8842	COAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.R263H	DO8514	COAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.R263H	DO12214	GBM	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7222
p.L269F	DO16530	KIRC	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.6981
p.R260L	DO20915	KIRP	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.1944
p.S264R	DO229038	LICA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.75
p.P275H	DO229008	LICA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.6944
p.R260C	DO48682	LIRI	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.1944
p.V273L	DO51192	LUAD	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.3056
p.E270G	DO52655	MALY	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.7199
p.V273A	DO51474	PACA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.3056
p.S264N	DO229259	THCA	ICGC	LLITPFPS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	DEG_SCF_FBW7_1	265:272	LLITPFPS	FBXW7	0.9976	More...
Q9P278	Folliculin-interacting protein 2	DEG_SCF_FBW7_1	248:255	LLITPFPS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons