DegronMD

Uniprot ID: Q9P278

Source protein: Folliculin-interacting protein 2

Source gene: FNIP2

Class: DEG_SCF_TRCP1_1

Location: 236:242

E3 ligase: BTRC

DEGRON score: 0.9995

ASA_SCORE: 62.5

COIL: 0.7801

CONS_SCORE: 0.4812

DSS_SCORE: 0.6061

HELIX: 0.1127

FCONS_SCORE: 1.483

RIG_SCORE: 0.68

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R241P	TCGA-86-8673	LUAD	TCGA	DSGIARS	DEG_SCF_TRCP1_1	0.6401
p.D234H	TCGA-A8-A09M	BRCA	TCGA	DSGIARS	DEG_SCF_TRCP1_1	0.2778
p.M226V	TCGA-B5-A3FA	UCEC	TCGA	DSGIARS	DEG_SCF_TRCP1_1	0.0556
p.R241Q	TCGA-E6-A1LX	UCEC	TCGA	DSGIARS	DEG_SCF_TRCP1_1	0.6218
p.R236H	DO222790	COCA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.8244
p.C235Y	DO21053	LAML	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.3056
p.A242S	DO229015	LICA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.7588
p.A242S	DO47578	SKCM	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.7588
p.V247D	DO38567	STAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6389
p.G233S	DO51761	STAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.25
p.S246N	SIDM01588	Endometrial Carcinoma	GDSC	DSGIARS	DEG_SCF_TRCP1_1	0.2222
p.S246N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGIARS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	DEG_SCF_TRCP1_1	253:259	DSGIARS	BTRC	0.9919	More...
Q9P278	Folliculin-interacting protein 2	DEG_SCF_TRCP1_1	236:242	DSGIARS	BTRC	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons