DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: DEG_SCF_TRCP1_1

Location: 253:259

E3 ligase: BTRC

DEGRON score: 0.9919

ASA_SCORE: 63.6

COIL: 0.6824

CONS_SCORE: 0.4963

DSS_SCORE: 0.4773

HELIX: 0.0853

FCONS_SCORE: 1.3245

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A254T	DO225346	BRCA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.7139
p.R263C	DO9490	COAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R263C	DO36463	READ	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R263C	DO41235	UCEC	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R263H	DO8842	COAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R263H	DO8514	COAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R263H	DO12214	GBM	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6667
p.R251Q	DO223101	ESCA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.2778
p.R260L	DO20915	KIRP	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.3056
p.S264R	DO229038	LICA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6389
p.N246K	DO229009	LICA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.1389
p.R260C	DO48682	LIRI	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.3056
p.S248A	DO48032	STAD	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.1944
p.S264N	DO229259	THCA	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.6389
p.S255N	DO42977	UCEC	ICGC	DSGIARS	DEG_SCF_TRCP1_1	0.7069
p.R258Q	SIDM00216	Colorectal Carcinoma	GDSC	DSGIARS	DEG_SCF_TRCP1_1	0.6218
p.R258Q	SNU-175	large_intestine	COSMIC	DSGIARS	DEG_SCF_TRCP1_1	0.6218
p.S249G	ESO51	oesophagus	COSMIC	DSGIARS	DEG_SCF_TRCP1_1	0.2222
p.D251G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIARS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	DEG_SCF_TRCP1_1	253:259	DSGIARS	BTRC	0.9919	More...
Q9P278	Folliculin-interacting protein 2	DEG_SCF_TRCP1_1	236:242	DSGIARS	BTRC	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons