DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_FBW7_2

Location: 3169:3175

E3 ligase: FBXW7

DEGRON score: 0.9368

ASA_SCORE: 83.5286

COIL: 0.8411

CONS_SCORE: 0.2391

DSS_SCORE: 0.6489

HELIX: 0.0799

FCONS_SCORE: 0.877

RIG_SCORE: 0.6202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3180G	TCGA-B5-A1MX	UCEC	TCGA	PETPSSE	DEG_SCF_FBW7_2	0.1944
p.E3180G	DO41999	UCEC	ICGC	PETPSSE	DEG_SCF_FBW7_2	0.1944
p.P3169L	TCGA-B5-A1MX	UCEC	TCGA	PETPSSE	DEG_SCF_FBW7_2	0.6471
p.P3169L	DO41999	UCEC	ICGC	PETPSSE	DEG_SCF_FBW7_2	0.6471
p.S3165N	TCGA-BB-7870	HNSC	TCGA	PETPSSE	DEG_SCF_FBW7_2	0.2222
p.S3165N	DO14378	HNSC	ICGC	PETPSSE	DEG_SCF_FBW7_2	0.2222
p.G3163E	TCGA-FR-A7U9	SKCM	TCGA	PETPSSE	DEG_SCF_FBW7_2	0.1667
p.G3163E	DO48546	SKCM	ICGC	PETPSSE	DEG_SCF_FBW7_2	0.1667
p.E3175D	SIDM00789	Colorectal Carcinoma	GDSC	PETPSSE	DEG_SCF_FBW7_2	0.6758
p.E3175D	ACH-000997	Colon/Colorectal Cancer	CCLE	PETPSSE	DEG_SCF_FBW7_2	0.6758
p.E3175D	HCT-15	large_intestine	COSMIC	PETPSSE	DEG_SCF_FBW7_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_FBW7_2	3169:3175	PETPSSE	FBXW7	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons