DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_FBW7_2

Location: 3675:3681

E3 ligase: FBXW7

DEGRON score: 0.536

ASA_SCORE: 105.0429

COIL: 0.9286

CONS_SCORE: 0.3066

DSS_SCORE: 0.7491

HELIX: 0.0137

FCONS_SCORE: 0.9827

RIG_SCORE: 0.6936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3666A	TCGA-BQ-7048	KIRP	TCGA	VETPTVE	DEG_SCF_FBW7_2	0.0833
p.T3666A	DO20936	KIRP	ICGC	VETPTVE	DEG_SCF_FBW7_2	0.0833
p.P3678L	TCGA-D3-A3MV	SKCM	TCGA	VETPTVE	DEG_SCF_FBW7_2	0.7582
p.P3678L	DO37727	SKCM	ICGC	VETPTVE	DEG_SCF_FBW7_2	0.7582
p.E3676Q	TCGA-G2-A2EJ	BLCA	TCGA	VETPTVE	DEG_SCF_FBW7_2	0.5633
p.E3676Q	DO554	BLCA	ICGC	VETPTVE	DEG_SCF_FBW7_2	0.5633
p.E3668D	DO228947	LICA	ICGC	VETPTVE	DEG_SCF_FBW7_2	0.1389
p.T3679A	SIDM01090	Colorectal Carcinoma	GDSC	VETPTVE	DEG_SCF_FBW7_2	0.6028
p.T3679A	ACH-000943	Colon/Colorectal Cancer	CCLE	VETPTVE	DEG_SCF_FBW7_2	0.6028
p.T3679A	RKO	large_intestine	COSMIC	VETPTVE	DEG_SCF_FBW7_2	0.6028
p.P3678S	ACH-002396	Bone Cancer	CCLE	VETPTVE	DEG_SCF_FBW7_2	0.6752
p.P3678S	Sarc9371	bone	COSMIC	VETPTVE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_FBW7_2	3675:3681	VETPTVE	FBXW7	0.536	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons