DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: LIG_APCC_ABBAyCdc20_2

Location: 4340:4346

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9651

ASA_SCORE: 101.7714

COIL: 0.7449

CONS_SCORE: 0.2495

DSS_SCORE: 0.7352

HELIX: 0.0576

FCONS_SCORE: 1.0568

RIG_SCORE: 0.6299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4347Q	TCGA-56-7822	LUSC	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E4347Q	DO26638	LUSC	ICGC	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S4333Y	TCGA-AA-A010	COAD	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.5833
p.D4336N	TCGA-EE-A182	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R4340K	TCGA-ER-A19A	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.6126
p.H4344N	TCGA-F7-A624	HNSC	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.7423
p.K4355E	TCGA-FR-A44A	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	LIG_APCC_ABBAyCdc20_2	4340:4346	RLSLHEE	APC,CDC20,FZR1	0.9651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons