DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_FBW7_1

Location: 1639:1646

E3 ligase: FBXW7

DEGRON score: 0.9309

ASA_SCORE: 82.825

COIL: 0.9388

CONS_SCORE: 0.3808

DSS_SCORE: 0.5105

HELIX: 0.0136

FCONS_SCORE: 1.0434

RIG_SCORE: 0.6858

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1635D	TCGA-D3-A3CE	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	0.2222
p.E1635D	DO37405	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.2222
p.P1644L	TCGA-D3-A8GI	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	0.6471
p.P1644L	DO50284	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.6471
p.P1644S	TCGA-D3-A8GI	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	0.5641
p.P1644S	DO50284	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.5641
p.S1649L	TCGA-RP-A695	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	0.25
p.S1649L	DO51270	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.25
p.A1645V	DO227802	COCA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.5825
p.A1645V	DO23132	LINC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.5825
p.S1645Y	DO14307	HNSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.712
p.P1643T	DO232033	LICA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.7031
p.A1645S	DO45083	LINC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.6477
p.T1653N	DO224539	LUSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1389
p.T1653N	DO231010	LUSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1389
p.M1641I	DO220882	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.6507
p.P1650L	DO220886	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.2222
p.G1634R	DO220903	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1633N	DO222632	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1667
p.L1633F	DO229446	SKCA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1667
p.P1637L	DO37406	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.2778
p.V1652I	DO51784	STAD	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	0.1667
p.V1652I	SIDM00429	B-Lymphoblastic Leukemia	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	0.1667
p.V1652I	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	0.1667
p.R1636K	SIDM01151	Hepatocellular Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	0.25
p.R1636K	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	0.25
p.R1636K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	0.25
p.A1630V	SIDM00454	Rhabdomyosarcoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	0.0833
p.S1637L	ACH-002508	Skin Cancer	CCLE	ITMTPPAS	DEG_SCF_FBW7_1	0.2778
p.V1645I	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	0.7076
p.S1651F	M14	skin	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITMTPPAS

Degron related mutations and impact score

Drug responses associated with ANK3 mutations

All proteins holding degron of ITMTPPAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_FBW7_1	1639:1646	ITMTPPAS	FBXW7	0.9309	More...