DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_FBW7_2

Location: 3584:3591

E3 ligase: FBXW7

DEGRON score: 0.9806

ASA_SCORE: 98.6625

COIL: 0.9383

CONS_SCORE: 0.3163

DSS_SCORE: 0.8608

HELIX: 0.0386

FCONS_SCORE: 1.0754

RIG_SCORE: 0.5957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3587M	TCGA-A5-A0VP	UCEC	TCGA	PARTPTDE	DEG_SCF_FBW7_2	0.7423
p.T3587M	DO50786	LICA	ICGC	PARTPTDE	DEG_SCF_FBW7_2	0.7423
p.T3587M	DO42600	UCEC	ICGC	PARTPTDE	DEG_SCF_FBW7_2	0.7423
p.D3590G	TCGA-B5-A11E	UCEC	TCGA	PARTPTDE	DEG_SCF_FBW7_2	0.6087
p.D3590G	DO41644	UCEC	ICGC	PARTPTDE	DEG_SCF_FBW7_2	0.6087
p.E3591K	TCGA-XF-AAN2	BLCA	TCGA	PARTPTDE	DEG_SCF_FBW7_2	0.7022
p.E3591K	DO219052	BLCA	ICGC	PARTPTDE	DEG_SCF_FBW7_2	0.7022
p.R3586K	DO23518	LIRI	ICGC	PARTPTDE	DEG_SCF_FBW7_2	0.6126
p.P3584S	SIDM01060	Melanoma	GDSC	PARTPTDE	DEG_SCF_FBW7_2	0.6752
p.P3584S	ACH-000882	Skin Cancer	CCLE	PARTPTDE	DEG_SCF_FBW7_2	0.6752
p.P3584S	IGR-1	skin	COSMIC	PARTPTDE	DEG_SCF_FBW7_2	0.6752
p.R3574H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PARTPTDE	DEG_SCF_FBW7_2	0.0556
p.R3574H	ACH-000918	Leukemia	CCLE	PARTPTDE	DEG_SCF_FBW7_2	0.0556
p.R3574H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PARTPTDE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_FBW7_2	3584:3591	PARTPTDE	FBXW7	0.9806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons