DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_SKP2-CKS1_1

Location: 1605:1612

E3 ligase: SKP2,CSK1

DEGRON score: 0.9959

ASA_SCORE: 76.5125

COIL: 0.7654

CONS_SCORE: 0.3445

DSS_SCORE: 0.4043

HELIX: 0.1216

FCONS_SCORE: 0.9983

RIG_SCORE: 0.7691

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1608V	TCGA-AX-A1CE	UCEC	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.5825
p.A1608V	DO42280	UCEC	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.5825
p.T1619M	TCGA-B5-A11E	UCEC	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T1619M	DO35597	PBCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T1619M	DO41644	UCEC	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T1606M	TCGA-BR-4201	STAD	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.6312
p.T1606M	TCGA-L5-A8NM	ESCA	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.6312
p.T1606M	DO38707	STAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.6312
p.S1621F	TCGA-FS-A1ZK	SKCM	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S1621F	DO222710	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S1621F	DO218840	SKCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S1621F	DO37474	SKCM	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T1609M	TCGA-HT-8011	LGG	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7423
p.T1609M	DO22197	LGG	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7423
p.E1607K	TCGA-WE-AAA3	SKCM	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E1607K	DO51295	SKCM	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7022
p.D1613G	DO7783	COAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P1610S	DO228935	COCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.6752
p.S1619A	DO50450	ESAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T1598N	DO228971	LICA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T1598N	DO229019	LICA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1595F	DO220877	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D1613N	DO222578	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D1613Y	DO222708	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S1619C	SIDM00375	Head and Neck Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SIDM00240	Cervical Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SIDM00381	Cervical Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SIDM01622	Breast Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SIDM01446	Glioblastoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SKG-IIIa	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	OMC-1	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S1619C	SKN-3	upper_aerodigestive_tract	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.F1620L	SIDM00118	Colorectal Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.F1620L	ACH-001081	Colon/Colorectal Cancer	CCLE	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.F1620L	HCC2998	large_intestine	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.S1612C	OMC-1	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7541
p.S1612C	SKN-3	upper_aerodigestive_tract	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7541
p.S1612C	SKG-IIIa	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTEATPLK

Degron related mutations and impact score

Drug responses associated with ANK3 mutations

All proteins holding degron of VTEATPLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_SKP2-CKS1_1	1605:1612	VTEATPLK	SKP2,CSK1	0.9959	More...