DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SCF_FBW7_1

Location: 3576:3583

E3 ligase: FBXW7

DEGRON score: 0.7097

ASA_SCORE: 92.1125

COIL: 0.9475

CONS_SCORE: 0.3022

DSS_SCORE: 0.8092

HELIX: 0.0155

FCONS_SCORE: 0.9724

RIG_SCORE: 0.587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3583M	TCGA-06-0154	GBM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	TCGA-IG-A3I8	ESCA	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	DO12292	GBM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	DO32817	PACA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	SIDM01135	Pancreatic Carcinoma	GDSC	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	ACH-000060	Pancreatic Cancer	CCLE	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.T3583M	PANC-10-05	pancreas	COSMIC	PATTPDTT	DEG_SCF_FBW7_1	0.7423
p.E3572Q	TCGA-BH-A1EV	BRCA	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.2222
p.E3572Q	DO1797	BRCA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.2222
p.E3572D	TCGA-EE-A2A2	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.2222
p.E3572D	DO37583	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.2222
p.T3582I	TCGA-EE-A3AB	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.5966
p.T3582I	DO222670	MELA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.5966
p.T3582I	DO38057	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.5966
p.P3580T	TCGA-ER-A19G	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.7031
p.P3580T	DO47284	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.7031
p.P3576L	TCGA-GN-A4U4	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.6471
p.P3576L	DO51256	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.6471
p.T3582A	TCGA-T3-A92N	HNSC	TCGA	PATTPDTT	DEG_SCF_FBW7_1	0.6028
p.T3582A	DO219073	HNSC	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.6028
p.T3578R	DO231114	LUSC	ICGC	PATTPDTT	DEG_SCF_FBW7_1	0.6765
p.R3574H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PATTPDTT	DEG_SCF_FBW7_1	0.2778
p.R3574H	ACH-000918	Leukemia	CCLE	PATTPDTT	DEG_SCF_FBW7_1	0.2778
p.R3574H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPDTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SCF_FBW7_1	3576:3583	PATTPDTT	FBXW7	0.7097	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons