DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_APCC_DBOX_1

Location: 543:551

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5285

ASA_SCORE: 28.8889

COIL: 0.4292

CONS_SCORE: 0.5827

DSS_SCORE: 0.1523

HELIX: 0.0026

FCONS_SCORE: 1.4219

RIG_SCORE: 0.8259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R544W	TCGA-DU-6392	LGG	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.8634
p.A540E	TCGA-SX-A7SS	KIRP	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.25
p.R540Q	DO222427	BTCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.25
p.E559K	DO14694	HNSC	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.1111
p.E559K	DO229051	LICA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.1111
p.A534E	DO49794	KIRP	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.0833
p.R538W	DO22237	LGG	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.1944
p.Q555H	DO233296	NACA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.2222
p.A542V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	0.3056
p.A542V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	0.3056
p.A536V	ACH-001127	Leukemia	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	0.1389
p.A536V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_DBOX_1	556:564	SRDRLIHVL	APC,CDC20,FZR1	0.5378	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_APCC_DBOX_1	543:551	SRDRLIHVL	APC,CDC20,FZR1	0.5285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons