DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_APCC_DBOX_1

Location: 740:748

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8954

ASA_SCORE: 80.3556

COIL: 0.2296

CONS_SCORE: 0.3225

DSS_SCORE: 0.5632

HELIX: 0.7548

FCONS_SCORE: 1.0131

RIG_SCORE: 0.8056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R743H	TCGA-06-2563	GBM	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	0.7133
p.R743H	TCGA-AA-3684	COAD	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	0.7133
p.R731C	TCGA-B5-A3FC	UCEC	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	0.0833
p.R731H	TCGA-CD-8531	STAD	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	0.0833
p.Q751R	TCGA-D9-A6EC	SKCM	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	0.25
p.R744H	DO229355	BTCA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.8244
p.R744H	ACH-000258	Breast Cancer	CCLE	MRQRLAELR	DEG_APCC_DBOX_1	0.8244
p.R744H	DU-4475	breast	COSMIC	MRQRLAELR	DEG_APCC_DBOX_1	0.8244
p.R737H	DO8802	COAD	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.25
p.R737H	DO11525	GBM	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.25
p.R746L	DO228974	LICA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.8428
p.G748C	DO229038	LICA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.76
p.Q745R	DO50291	SKCM	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	0.7329
p.R752W	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	0.2222
p.R752W	SIDM01190	Bladder Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	0.2222
p.R752W	SIDM00929	Chondrosarcoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	0.2222
p.R752W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	0.2222
p.R750H	SIDM01001	Breast Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	0.2778
p.R750H	DU-4475	breast	COSMIC	MRQRLAELR	DEG_APCC_DBOX_1	0.2778
p.P753L	ACH-001864	Bile Duct Cancer	CCLE	MRQRLAELR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_APCC_DBOX_1	740:748	MRQRLAELR	APC,CDC20,FZR1	0.8954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons