DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MRQRLAELR
Uniprot ID:
O60336
Source protein:
Mitogen-activated protein kinase-binding protein 1
Source gene:
MAPKBP1
Class:
DEG_APCC_DBOX_1
Location:
740:748
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8954
ASA_SCORE:
80.3556
COIL:
0.2296
CONS_SCORE:
0.3225
DSS_SCORE:
0.5632
HELIX:
0.7548
FCONS_SCORE:
1.0131
RIG_SCORE:
0.8056
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R746L
DO228974
LICA
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.8428
p.R744H
DO229355
BTCA
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.8244
p.R744H
ACH-000258
Breast Cancer
CCLE
MRQRLAELR
DEG_APCC_DBOX_1
0.8244
p.R744H
DU-4475
breast
COSMIC
MRQRLAELR
DEG_APCC_DBOX_1
0.8244
p.G748C
DO229038
LICA
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.76
p.Q745R
DO50291
SKCM
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.7329
p.R743H
TCGA-06-2563
GBM
TCGA
MRQRLAELR
DEG_APCC_DBOX_1
0.7133
p.R743H
TCGA-AA-3684
COAD
TCGA
MRQRLAELR
DEG_APCC_DBOX_1
0.7133
p.R750H
SIDM01001
Breast Carcinoma
GDSC
MRQRLAELR
DEG_APCC_DBOX_1
0.2778
p.R750H
DU-4475
breast
COSMIC
MRQRLAELR
DEG_APCC_DBOX_1
0.2778
p.Q751R
TCGA-D9-A6EC
SKCM
TCGA
MRQRLAELR
DEG_APCC_DBOX_1
0.25
p.R737H
DO8802
COAD
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.25
p.R737H
DO11525
GBM
ICGC
MRQRLAELR
DEG_APCC_DBOX_1
0.25
p.R752W
SIDM00759
Non-Small Cell Lung Carcinoma
GDSC
MRQRLAELR
DEG_APCC_DBOX_1
0.2222
p.R752W
SIDM01190
Bladder Carcinoma
GDSC
MRQRLAELR
DEG_APCC_DBOX_1
0.2222
p.R752W
SIDM00929
Chondrosarcoma
GDSC
MRQRLAELR
DEG_APCC_DBOX_1
0.2222
p.R752W
SIDM01510
Non-Small Cell Lung Carcinoma
GDSC
MRQRLAELR
DEG_APCC_DBOX_1
0.2222
p.P753L
ACH-001864
Bile Duct Cancer
CCLE
MRQRLAELR
DEG_APCC_DBOX_1
0.1944
p.R731C
TCGA-B5-A3FC
UCEC
TCGA
MRQRLAELR
DEG_APCC_DBOX_1
0.0833
p.R731H
TCGA-CD-8531
STAD
TCGA
MRQRLAELR
DEG_APCC_DBOX_1
0.0833
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Drug responses associated with MAPKBP1 mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of MRQRLAELR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60336
Mitogen-activated protein kinase-binding protein 1
DEG_APCC_DBOX_1
740:748
MRQRLAELR
APC,CDC20,FZR1
0.8954
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