DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_APCC_DBOX_1

Location: 976:984

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9711

ASA_SCORE: 76.1333

COIL: 0.6856

CONS_SCORE: 0.3038

DSS_SCORE: 0.6025

HELIX: 0.0624

FCONS_SCORE: 1.0453

RIG_SCORE: 0.6799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V972E	TCGA-56-A62T	LUSC	TCGA	ARGTLGRVY	DEG_APCC_DBOX_1	0.2222
p.V966E	DO219144	LUSC	ICGC	ARGTLGRVY	DEG_APCC_DBOX_1	0.0556
p.R977W	ACH-000960	Leukemia	CCLE	ARGTLGRVY	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_APCC_DBOX_1	976:984	ARGTLGRVY	APC,CDC20,FZR1	0.9711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons