DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_SCF_FBW7_2

Location: 1060:1066

E3 ligase: FBXW7

DEGRON score: 0.9797

ASA_SCORE: 82.9571

COIL: 0.6326

CONS_SCORE: 0.3185

DSS_SCORE: 0.8344

HELIX: 0.3481

FCONS_SCORE: 1.1106

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1072R	TCGA-94-8491	LUSC	TCGA	PQTPDQE	DEG_SCF_FBW7_2	0.1667
p.Q1065H	DO222884	COCA	ICGC	PQTPDQE	DEG_SCF_FBW7_2	0.647
p.H1066R	DO219174	LUSC	ICGC	PQTPDQE	DEG_SCF_FBW7_2	0.8244
p.P1063L	SIDM00392	Melanoma	GDSC	PQTPDQE	DEG_SCF_FBW7_2	0.7582
p.P1063L	SK-MEL-30	skin	COSMIC	PQTPDQE	DEG_SCF_FBW7_2	0.7582
p.P1057L	ACH-000810	Skin Cancer	CCLE	PQTPDQE	DEG_SCF_FBW7_2	0.25
p.P1057L	SK-MEL-30	skin	COSMIC	PQTPDQE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SCF_FBW7_2	1060:1066	PQTPDQE	FBXW7	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons