DegronMD - Q96S96(PEBP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M177I	TCGA-05-4396	LUAD	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.1389
p.M177I	TCGA-EE-A183	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.1389
p.M177I	DO23838	LUAD	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.1389
p.M177I	DO37715	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.1389
p.Q157H	TCGA-5L-AAT1	BRCA	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.0833
p.Q157H	DO219594	BRCA	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.0833
p.P166H	TCGA-D3-A2JP	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.6583
p.P166H	DO47407	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.6583
p.E168K	TCGA-EE-A17Y	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.7022
p.E168K	TCGA-EE-A2GO	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.7022
p.E168K	DO37823	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.7022
p.E168K	DO47459	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation altering degron motif	0.7022
p.S163C	DO233134	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.25
p.L156R	DO233748	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.0556
p.R172G	DO51014	LAML	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.2778
p.D178E	DO229008	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.1111
p.R172Q	SIDM00360	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.2778
p.R172Q	ACH-000347	Pancreatic Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.2778
p.R172Q	QGP-1	pancreas	COSMIC	PKENK	DEG_APCC_KENBOX_2	166:170	Mutation rewiring degron network	0.2778

Kaplan plot for PEBP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEBP4

UniProt ID: Q96S96

Entrez ID: 157310

Protein name: Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PEBP4 in