DegronMD - Q8IZ63(PRR22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P185L	TCGA-EB-A6R0	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.25
p.P185L	DO48646	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.25
p.P188H	DO50958	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6583
p.P193L	DO224596	PACA	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.P187H	DO229257	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.A202V	DO229216	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.0556
p.P184S	DO229227	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.2222
p.P188A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6392
p.P188A	SIDM00808	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6392
p.P188A	SIDM01254	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6392
p.A202E	SIDM00490	Glioma	GDSC	PKENK	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons