DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SCF_FBW7_1

Location: 889:896

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 101.825

COIL: 0.9598

CONS_SCORE: 0.6109

DSS_SCORE: 0.6595

HELIX: 0.011

FCONS_SCORE: 1.0505

RIG_SCORE: 0.6421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P902H	TCGA-EO-A22R	UCEC	TCGA	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.P902H	DO42713	UCEC	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.R897W	TCGA-RP-A694	SKCM	TCGA	VKATPMPS	DEG_SCF_FBW7_1	0.3056
p.R897W	DO51269	SKCM	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.3056
p.D905E	DO228952	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.0833
p.Q906K	DO229034	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.P902T	DO50913	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.P902S	DO222908	MELA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.S888Y	DO43154	UCEC	ICGC	VKATPMPS	DEG_SCF_FBW7_1	0.3056
p.P902L	SIDM00931	Thyroid Gland Carcinoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.P902L	CAL-62	thyroid	COSMIC	VKATPMPS	DEG_SCF_FBW7_1	0.1667
p.A891T	SIDM00081	Melanoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	0.6028
p.A891T	SIDM01746	Osteosarcoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	0.6028
p.A891T	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	0.6028
p.S890F	ACH-000961	Endometrial/Uterine Cancer	CCLE	VKATPMPS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SCF_FBW7_1	889:896	VKATPMPS	FBXW7	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons