DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SPOP_SBC_1

Location: 808:812

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 98.7

COIL: 0.8592

CONS_SCORE: 0.6229

DSS_SCORE: 0.5762

HELIX: 0.1254

FCONS_SCORE: 1.0118

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A815V	TCGA-AB-2833	LAML	TCGA	AKTTT	DEG_SPOP_SBC_1	0.25
p.A815V	DO21679	LAML	ICGC	AKTTT	DEG_SPOP_SBC_1	0.25
p.K802N	TCGA-CD-5800	STAD	TCGA	AKTTT	DEG_SPOP_SBC_1	0.2778
p.K802N	DO38431	STAD	ICGC	AKTTT	DEG_SPOP_SBC_1	0.2778
p.A817P	DO234285	ESAD	ICGC	AKTTT	DEG_SPOP_SBC_1	0.1944
p.A817P	SIDM00704	Small Cell Lung Carcinoma	GDSC	AKTTT	DEG_SPOP_SBC_1	0.1944
p.P805T	DO228974	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.25
p.D809E	DO229019	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.6758
p.S801Y	DO229036	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.1389
p.P814T	DO229041	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.2778
p.A802D	DO232224	PBCA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.2778
p.A808V	SIDM00732	Glioblastoma	GDSC	AKTTT	DEG_SPOP_SBC_1	0.5825
p.A808V	D-263MG	central_nervous_system	COSMIC	AKTTT	DEG_SPOP_SBC_1	0.5825
p.S803G	SIDM00816	Kidney Carcinoma	GDSC	AKTTT	DEG_SPOP_SBC_1	0.6389
p.S803G	RCC-MF	kidney	COSMIC	AKTTT	DEG_SPOP_SBC_1	0.6389
p.A811V	ACH-001484	Leukemia	CCLE	AKTTT	DEG_SPOP_SBC_1	0.6936
p.A811V	ACH-001485	Leukemia	CCLE	AKTTT	DEG_SPOP_SBC_1	0.6936
p.A802V	ACH-001515	Cervical Cancer	CCLE	AKTTT	DEG_SPOP_SBC_1	0.2778
p.P807Q	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	AKTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	808:812	AKTTT	SPOP	0.9982	More...
Q05682	Caldesmon	DEG_SPOP_SBC_1	79:83	AKTTT	SPOP	0.7433	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11988:11992	AKTTT	SPOP	0.9876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons