DegronMD

Uniprot ID: Q05682

Source protein: Caldesmon

Source gene: CALD1

Class: DEG_SPOP_SBC_1

Location: 79:83

E3 ligase: SPOP

DEGRON score: 0.7433

ASA_SCORE: 99.68

COIL: 0.7902

CONS_SCORE: 0.2664

DSS_SCORE: 0.7268

HELIX: 0.1862

FCONS_SCORE: 0.6883

RIG_SCORE: 0.6839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E78K	TCGA-AC-A23H	BRCA	TCGA	AKTTT	DEG_SPOP_SBC_1	0.3056
p.D92Y	TCGA-KL-8335	KICH	TCGA	AKTTT	DEG_SPOP_SBC_1	0.0833
p.E72K	DO2401	BRCA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.1389
p.R93H	DO234401	ESAD	ICGC	AKTTT	DEG_SPOP_SBC_1	0.0556
p.R93H	DO229213	THCA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.0556
p.D86Y	DO220343	KICH	ICGC	AKTTT	DEG_SPOP_SBC_1	0.6944
p.F90L	DO221125	MALY	ICGC	AKTTT	DEG_SPOP_SBC_1	0.1389
p.E92K	DO42201	UCEC	ICGC	AKTTT	DEG_SPOP_SBC_1	0.0833
p.R93C	DO42608	UCEC	ICGC	AKTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	808:812	AKTTT	SPOP	0.9982	More...
Q05682	Caldesmon	DEG_SPOP_SBC_1	79:83	AKTTT	SPOP	0.7433	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11988:11992	AKTTT	SPOP	0.9876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons