DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11988:11992

E3 ligase: SPOP

DEGRON score: 0.9876

ASA_SCORE: 86.08

COIL: 0.677

CONS_SCORE: 0

DSS_SCORE: 0.4275

HELIX: 0.0178

FCONS_SCORE: 0

RIG_SCORE: 0.8083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T11981K	TCGA-33-4566	LUSC	TCGA	AKTTT	DEG_SPOP_SBC_1	0.5833
p.T11981K	DO228952	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.5833
p.T11981K	DO26790	LUSC	ICGC	AKTTT	DEG_SPOP_SBC_1	0.5833
p.S11984G	DO222874	COCA	ICGC	AKTTT	DEG_SPOP_SBC_1	0.2222
p.T11986I	SIDM00455	Pancreatic Carcinoma	GDSC	AKTTT	DEG_SPOP_SBC_1	0.2778
p.T11986I	ACH-000599	Pancreatic Cancer	CCLE	AKTTT	DEG_SPOP_SBC_1	0.2778
p.T11986I	PA-TU-8902	pancreas	COSMIC	AKTTT	DEG_SPOP_SBC_1	0.2778
p.P11985L	SIDM00867	Glioblastoma	GDSC	AKTTT	DEG_SPOP_SBC_1	0.25
p.P11985L	ACH-000863	Brain Cancer	CCLE	AKTTT	DEG_SPOP_SBC_1	0.25
p.P11985L	DBTRG-05MG	central_nervous_system	COSMIC	AKTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	808:812	AKTTT	SPOP	0.9982	More...
Q05682	Caldesmon	DEG_SPOP_SBC_1	79:83	AKTTT	SPOP	0.7433	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11988:11992	AKTTT	SPOP	0.9876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons