DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SCF_FBW7_2

Location: 520:525

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 94.2

COIL: 0.9458

CONS_SCORE: 0.561

DSS_SCORE: 0.4524

HELIX: 0.0207

FCONS_SCORE: 0.9878

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L530I	TCGA-19-5956	GBM	TCGA	VTPPPE	DEG_SCF_FBW7_2	0.1944
p.L530I	DO13863	GBM	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.1944
p.L530I	SIDM01043	Other Sarcomas	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.1944
p.L530I	ESS-1	endometrium	COSMIC	VTPPPE	DEG_SCF_FBW7_2	0.1944
p.V534I	TCGA-32-2616	GBM	TCGA	VTPPPE	DEG_SCF_FBW7_2	0.0833
p.V534I	DO13462	GBM	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.0833
p.D519Y	TCGA-55-7576	LUAD	TCGA	VTPPPE	DEG_SCF_FBW7_2	0.3056
p.D519Y	DO24431	LUAD	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.3056
p.K532T	TCGA-CC-5262	LIHC	TCGA	VTPPPE	DEG_SCF_FBW7_2	0.25
p.K532T	DO22953	LIHC	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.25
p.M514I	TCGA-DA-A1I1	SKCM	TCGA	VTPPPE	DEG_SCF_FBW7_2	0.1667
p.M514I	DO37966	SKCM	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.1667
p.P524L	DO1094	BRCA	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.6471
p.N533K	DO229029	LICA	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.1111
p.P522Q	DO229038	LICA	ICGC	VTPPPE	DEG_SCF_FBW7_2	0.7035
p.T526A	SIDM01174	Cervical Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM00803	Kidney Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM00210	Ovarian Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM00666	Glioma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM01757	Bladder Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.T526A	SIDM01491	Colorectal Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.75
p.C535G	SIDM01190	Bladder Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	0.0556
p.C535G	TCCSUP	urinary_tract	COSMIC	VTPPPE	DEG_SCF_FBW7_2	0.0556
p.P511S	ACH-000547	Bladder Cancer	CCLE	VTPPPE	DEG_SCF_FBW7_2	0.0833
p.P511S	HT-1197	urinary_tract	COSMIC	VTPPPE	DEG_SCF_FBW7_2	0.0833
p.P511L	EFO-27	ovary	COSMIC	VTPPPE	DEG_SCF_FBW7_2	0.0833
p.E521Q	NCI-H2342	lung	COSMIC	VTPPPE	DEG_SCF_FBW7_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SCF_FBW7_2	520:525	VTPPPE	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPPPE

Degron related mutations and impact score

Drug responses associated with MAP4 mutations

All proteins holding degron of VTPPPE