DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SIAH_1

Location: 879:887

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9953

ASA_SCORE: 80.6222

COIL: 0.9514

CONS_SCORE: 0.5349

DSS_SCORE: 0.5893

HELIX: 0.0192

FCONS_SCORE: 0.9293

RIG_SCORE: 0.676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G883W	TCGA-AX-A2HA	UCEC	TCGA	APAAGVVPS	DEG_SIAH_1	0.6714
p.G883W	DO42504	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	0.6714
p.A879V	TCGA-CQ-7068	HNSC	TCGA	APAAGVVPS	DEG_SIAH_1	0.5825
p.A879V	DO15551	HNSC	ICGC	APAAGVVPS	DEG_SIAH_1	0.5825
p.R897W	TCGA-RP-A694	SKCM	TCGA	APAAGVVPS	DEG_SIAH_1	0.0556
p.R897W	DO51269	SKCM	ICGC	APAAGVVPS	DEG_SIAH_1	0.0556
p.S888Y	DO43154	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	0.3056
p.P874T	DO42608	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	0.6389
p.L875V	201T	lung	COSMIC	APAAGVVPS	DEG_SIAH_1	0.2222
p.T872P	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	APAAGVVPS	DEG_SIAH_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27816	Microtubule-associated protein 4	DEG_SIAH_1	879:887	APAAGVVPS	SIAH1,SIAH2,SIAH3	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons