DegronMD

Uniprot ID: Q86YD7

Source protein: Protein FAM90A1

Source gene: FAM90A1

Class: DEG_APCC_KENBOX_2

Location: 78:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9665

ASA_SCORE: 96.58

COIL: 0.8552

CONS_SCORE: 0.7963

DSS_SCORE: 0.5934

HELIX: 0.065

FCONS_SCORE: 1.2965

RIG_SCORE: 0.67

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K79E	TCGA-2W-A8YY	CESC	TCGA	GKENL	DEG_APCC_KENBOX_2	0.7022
p.K79E	DO223732	CESC	ICGC	GKENL	DEG_APCC_KENBOX_2	0.7022
p.P87L	TCGA-A5-A0G2	UCEC	TCGA	GKENL	DEG_APCC_KENBOX_2	0.1944
p.P87L	DO41235	UCEC	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.N72K	TCGA-BA-4074	HNSC	TCGA	GKENL	DEG_APCC_KENBOX_2	0.1667
p.N72K	DO14710	HNSC	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1667
p.G78E	TCGA-D3-A2JO	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.6087
p.G78E	TCGA-GN-A263	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.6087
p.G78E	DO37766	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.6087
p.G78E	DO47619	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.6087
p.E77K	TCGA-D3-A8GL	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.3056
p.E77K	TCGA-EE-A182	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.3056
p.E77K	TCGA-EE-A29R	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.3056
p.E77K	DO37814	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.3056
p.E77K	DO37448	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.3056
p.E77K	DO50287	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.3056
p.P87S	TCGA-D7-6524	STAD	TCGA	GKENL	DEG_APCC_KENBOX_2	0.1944
p.P87S	DO38368	STAD	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.E75K	TCGA-EB-A5UM	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.25
p.E75K	TCGA-FW-A3R5	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.25
p.E75K	DO47282	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.25
p.E75K	DO37406	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.25
p.P71Q	DO229015	LICA	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1389
p.A91G	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00969	Ovarian Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM01126	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00200	Ewing's Sarcoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00654	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00694	Other Solid Cancers	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM01101	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00849	Kidney Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00254	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00032	Bladder Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00907	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00673	Breast Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.A91G	SIDM00760	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0833
p.K76N	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00200	Ewing's Sarcoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00654	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00694	Other Solid Cancers	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM01101	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00907	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00673	Breast Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.K76N	SIDM00760	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.2778
p.Q88R	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49454	Centromere protein F	DEG_APCC_KENBOX_2	3028:3032	GKENL	APC,CDC20,FZR1	0.9899	More...
Q15768	Ephrin-B3	DEG_APCC_KENBOX_2	199:203	GKENL	APC,CDC20,FZR1	0.8597	More...
Q86YD7	Protein FAM90A1	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9665	More...
Q8WXH0	Nesprin-2	DEG_APCC_KENBOX_2	1566:1570	GKENL	APC,CDC20,FZR1	0.7996	More...
A6NDY2	Putative protein FAM90A10	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9783	More...
A6NE21		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9697	More...
A6NEW6		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9477	More...
A6NIJ5	Putative protein FAM90A20P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9924	More...
A6NJQ4	Putative protein FAM90A8	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9623	More...
A6NKC0	Putative protein FAM90A7	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9691	More...
A6NNJ1	Putative protein FAM90A9	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9527	More...
A8MWA6	Putative protein FAM90A22	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9637	More...
A8MX19	Putative protein FAM90A12P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9571	More...
A8MXJ8	Putative protein FAM90A5P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
A8MXZ1	Putative protein FAM90A23	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9521	More...
D6RGX4	Putative protein FAM90A26	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9836	More...
P0C7V4	Putative protein FAM90A15P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9428	More...
P0C7W8	Putative protein FAM90A13P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9618	More...
P0C7W9	Putative protein FAM90A14	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
P0C7X0	Putative protein FAM90A24P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9616	More...
Q658T7	Putative protein FAM90A2P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENL

Degron related mutations and impact score

Drug responses associated with FAM90A1 mutations

All proteins holding degron of GKENL