DegronMD

Uniprot ID: O43314

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Source gene: PPIP5K2

Class: DEG_SCF_FBW7_1

Location: 1189:1196

E3 ligase: FBXW7

DEGRON score: 0.9997

ASA_SCORE: 73.7125

COIL: 0.8079

CONS_SCORE: 0.3173

DSS_SCORE: 0.529

HELIX: 0.0911

FCONS_SCORE: 1.0162

RIG_SCORE: 0.7177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1199L	TCGA-05-4250	LUAD	TCGA	ILPTPPAT	DEG_SCF_FBW7_1	0.6944
p.S1199L	DO24457	LUAD	ICGC	ILPTPPAT	DEG_SCF_FBW7_1	0.6944
p.K1203N	TCGA-E6-A1LZ	UCEC	TCGA	ILPTPPAT	DEG_SCF_FBW7_1	0.1389
p.K1203N	DO41398	UCEC	ICGC	ILPTPPAT	DEG_SCF_FBW7_1	0.1389
p.A1197T	SIDM01265	Plasma Cell Myeloma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.3056
p.A1197T	SIDM00889	Cervical Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.3056
p.A1197T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.3056
p.R1205C	SIDM01078	Small Cell Lung Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.1944
p.R1205C	SIDM00878	Breast Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.1944
p.P1188L	SIDM00140	Melanoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	0.3056
p.P1188L	COLO-792	skin	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	0.3056
p.L1190H	KU-19-19	urinary_tract	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	0.6202
p.P1193R	NCI-H1781	lung	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SCF_FBW7_1	1189:1196	ILPTPPAT	FBXW7	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons