DegronMD

Uniprot ID: O43314

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Source gene: PPIP5K2

Class: CBL_PTK

Location: 1117:1126

E3 ligase: CBL

DEGRON score: 0.866

ASA_SCORE: 68.43

COIL: 0.7242

CONS_SCORE: 0.2961

DSS_SCORE: 0.1348

HELIX: 0.1666

FCONS_SCORE: 0.9437

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1136I	TCGA-B5-A11Y	UCEC	TCGA	NGFELYSMVP	CBL_PTK	0.0556
p.V1136I	DO40889	UCEC	ICGC	NGFELYSMVP	CBL_PTK	0.0556
p.P1109L	TCGA-BF-A5ES	SKCM	TCGA	NGFELYSMVP	CBL_PTK	0.1111
p.P1109L	DO219456	SKCM	ICGC	NGFELYSMVP	CBL_PTK	0.1111
p.L1126F	TCGA-C4-A0F1	BLCA	TCGA	NGFELYSMVP	CBL_PTK	0.6981
p.L1126F	DO581	BLCA	ICGC	NGFELYSMVP	CBL_PTK	0.6981
p.Q1121K	TCGA-D7-A6F0	STAD	TCGA	NGFELYSMVP	CBL_PTK	0.6944
p.Q1121K	DO50120	STAD	ICGC	NGFELYSMVP	CBL_PTK	0.6944
p.R1113Q	DO230312	COCA	ICGC	NGFELYSMVP	CBL_PTK	0.2222
p.R1113Q	ACH-000806	Lymphoma	CCLE	NGFELYSMVP	CBL_PTK	0.2222
p.R1113Q	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	NGFELYSMVP	CBL_PTK	0.2222
p.F1125S	DO232761	PBCA	ICGC	NGFELYSMVP	CBL_PTK	0.7982
p.R1115H	SIDM01307	Colorectal Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	0.2778
p.R1121W	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	0.8634
p.R1121W	SIDM00230	Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	0.8634
p.R1121W	NCI-H2291	lung	COSMIC	NGFELYSMVP	CBL_PTK	0.8634
p.R1121W	IST-SL2	lung	COSMIC	NGFELYSMVP	CBL_PTK	0.8634
p.R1128Q	SIDM00329	Hodgkin's Lymphoma	GDSC	NGFELYSMVP	CBL_PTK	0.2778
p.R1128Q	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	NGFELYSMVP	CBL_PTK	0.2778
p.P1132L	ACH-000968	Skin Cancer	CCLE	NGFELYSMVP	CBL_PTK	0.1667
p.P1132L	COLO-792	skin	COSMIC	NGFELYSMVP	CBL_PTK	0.1667
p.S1118Y	ACH-002272	Lymphoma	CCLE	NGFELYSMVP	CBL_PTK	0.712
p.S1118Y	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	NGFELYSMVP	CBL_PTK	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	CBL_PTK	1117:1126	NGFELYSMVP	CBL	0.866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons