DegronMD

Uniprot ID: Q8NFC6

Source protein: Biorientation of chromosomes in cell division protein 1-like 1

Source gene: BOD1L1

Class: DEG_SCF_FBW7_1

Location: 1094:1100

E3 ligase: FBXW7

DEGRON score: 0.9462

ASA_SCORE: 86.4143

COIL: 0.9324

CONS_SCORE: 0.4405

DSS_SCORE: 0.6629

HELIX: 0.0331

FCONS_SCORE: 0.9047

RIG_SCORE: 0.582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1087K	TCGA-43-7656	LUSC	TCGA	LSTPSGS	DEG_SCF_FBW7_1	0.1389
p.E1087K	DO26424	LUSC	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.1389
p.G1109R	TCGA-73-4666	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	0.0833
p.G1109R	DO26230	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.0833
p.G1085V	TCGA-75-5125	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	0.0833
p.G1085V	DO24477	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.0833
p.Q1103H	TCGA-93-8067	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.Q1103H	DO25113	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.K1107N	TCGA-C8-A12Q	BRCA	TCGA	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.K1107N	DO3182	BRCA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.A1091E	DO229015	LICA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.Q1103K	DO229022	LICA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.S1108T	SIDM00934	Pancreatic Carcinoma	GDSC	LSTPSGS	DEG_SCF_FBW7_1	0.1111
p.A1091V	SIDM00217	Colorectal Carcinoma	GDSC	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.A1091V	ACH-000999	Colon/Colorectal Cancer	CCLE	LSTPSGS	DEG_SCF_FBW7_1	0.25
p.A1091V	SNU-1040	large_intestine	COSMIC	LSTPSGS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SCF_FBW7_1	1094:1100	LSTPSGS	FBXW7	0.9462	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons