DegronMD

Uniprot ID: Q8NFC6

Source protein: Biorientation of chromosomes in cell division protein 1-like 1

Source gene: BOD1L1

Class: DEG_APCC_KENBOX_2

Location: 1411:1415

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9093

ASA_SCORE: 113.38

COIL: 0.4786

CONS_SCORE: 0.3773

DSS_SCORE: 0.4757

HELIX: 0.4922

FCONS_SCORE: 1.0375

RIG_SCORE: 0.7798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1408G	TCGA-AA-3811	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.25
p.D1408G	DO7962	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.25
p.D1415N	TCGA-IE-A4EI	SARC	TCGA	KKEND	DEG_APCC_KENBOX_2	0.5821
p.D1415N	DO220153	SARC	ICGC	KKEND	DEG_APCC_KENBOX_2	0.5821
p.K1412T	DO233951	GACA	ICGC	KKEND	DEG_APCC_KENBOX_2	0.7306
p.G1404C	ACH-001456	Colon/Colorectal Cancer	CCLE	KKEND	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60285	NUAK family SNF1-like kinase 1	DEG_APCC_KENBOX_2	372:376	KKEND	APC,CDC20,FZR1	0.9873	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_APCC_KENBOX_2	1411:1415	KKEND	APC,CDC20,FZR1	0.9093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons