DegronMD

Uniprot ID: O60285

Source protein: NUAK family SNF1-like kinase 1

Source gene: NUAK1

Class: DEG_APCC_KENBOX_2

Location: 372:376

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9873

ASA_SCORE: 107.32

COIL: 0.571

CONS_SCORE: 0.4905

DSS_SCORE: 0.6622

HELIX: 0.394

FCONS_SCORE: 1.0734

RIG_SCORE: 0.6537

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R364Q	TCGA-30-1862	OV	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1111
p.R364Q	DO27988	OV	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1111
p.R364W	TCGA-44-A47F	LUAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1111
p.R364W	DO222864	COCA	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1111
p.R364W	DO24180	LUAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1111
p.S367L	TCGA-A6-5661	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1944
p.S367L	DO8634	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1944
p.S367L	SIDM01104	Melanoma	GDSC	KKEND	DEG_APCC_KENBOX_2	0.1944
p.S367L	SK-MEL-31	skin	COSMIC	KKEND	DEG_APCC_KENBOX_2	0.1944
p.R366W	TCGA-AA-A022	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1667
p.R366W	TCGA-FI-A2D0	UCEC	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1667
p.R366W	DO10647	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1667
p.R366W	DO43891	UCEC	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1667
p.S380A	TCGA-BR-8680	STAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.2222
p.S380A	DO47769	STAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.2222
p.E374Q	TCGA-BT-A3PH	BLCA	TCGA	KKEND	DEG_APCC_KENBOX_2	0.6744
p.E374Q	DO856	BLCA	ICGC	KKEND	DEG_APCC_KENBOX_2	0.6744
p.S380F	TCGA-CX-7086	HNSC	TCGA	KKEND	DEG_APCC_KENBOX_2	0.2222
p.S380F	DO15046	HNSC	ICGC	KKEND	DEG_APCC_KENBOX_2	0.2222
p.E363Q	TCGA-E7-A6MD	BLCA	TCGA	KKEND	DEG_APCC_KENBOX_2	0.0833
p.E363Q	DO219015	BLCA	ICGC	KKEND	DEG_APCC_KENBOX_2	0.0833
p.A384S	TCGA-HU-A4H0	STAD	TCGA	KKEND	DEG_APCC_KENBOX_2	0.1111
p.A384S	DO47785	STAD	ICGC	KKEND	DEG_APCC_KENBOX_2	0.1111
p.P386H	TCGA-IS-A3K7	SARC	TCGA	KKEND	DEG_APCC_KENBOX_2	0.0556
p.P386H	DO220168	SARC	ICGC	KKEND	DEG_APCC_KENBOX_2	0.0556
p.P386T	DO229032	LICA	ICGC	KKEND	DEG_APCC_KENBOX_2	0.0556

Drug responses associated with NUAK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00402	BLCA\|bladder	p.R595L (No)	GDSC	WZ4003	16.252
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G555S (No)	GDSC	WZ4003	17.992
SIDM00499	PRAD\|prostate	p.R330Q (No)	GDSC	WZ4003	54.65
SIDM00683	PRAD\|prostate	p.G281V (No)	GDSC	WZ4003	115.14
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.E346* (No)	GDSC	WZ4003	126.03
SIDM00453	PAAD\|pancreas	p.S503F (No)	GDSC	WZ4003	174.46
SIDM00174	HNSC\|head_and_neck	p.D584N (No)	GDSC	WZ4003	24.652
SIDM00685	GBM\|glioma	p.Q617_Y628delQNRPRPQYLKR (No)	GDSC	WZ4003	151.55
SIDM00381	CESC\|cervix	p.K391R (No)	GDSC	WZ4003	68.796
SIDM01090	COREAD\|large_intestine	p.I91T (No)	GDSC	WZ4003	55.332
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.T155A (No)	GDSC	WZ4003	59.673
SIDM01020	MM\|myeloma	p.S488L (No)	GDSC	WZ4003	57.792
SIDM00129	SKCM\|melanoma	p.R230* (No)	GDSC	WZ4003	4.769
SIDM00216	COREAD\|large_intestine	p.F637V (No)	GDSC	WZ4003	39.724
SIDM01114	PRAD\|prostate	p.R629W (No)	GDSC	WZ4003	72.727
SIDM00282	COREAD\|large_intestine	p.P221H (No)	GDSC	WZ4003	220.07
SIDM00660	COREAD\|large_intestine	p.C657R (No)	GDSC	WZ4003	129.65
SIDM00789	COREAD\|large_intestine	p.D644E (No)	GDSC	WZ4003	4.3663
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V577M (No)	GDSC	WZ4003	20.215
SIDM00336	SKCM\|melanoma	p.R599L (No)	GDSC	WZ4003	42.449
SIDM00632	MM\|myeloma	p.S600N (No)	GDSC	WZ4003	8.6534
SIDM00120	PRAD\|prostate	p.Y55H (No)	GDSC	WZ4003	324.56
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.R595L (No)	GDSC	WZ4003	12.352
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R410H (No)	GDSC	WZ4003	13.166
SIDM00465	OV\|ovary	p.H47R (No)	GDSC	WZ4003	137.33
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.Y66S (No)	GDSC	WZ4003	356.55
SIDM00417	MM\|myeloma	p.S215I (No)	GDSC	WZ4003	27.232
SIDM00539	ESCA\|oesophagus	p.R271Q (No)	GDSC	WZ4003	219.04
SIDM01259	ALL\|lymphoblastic_leukemia	p.L140V (No)	GDSC	WZ4003	9.7296
SIDM00679	CESC\|cervix	p.S325F (No)	GDSC	WZ4003	276.45

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60285	NUAK family SNF1-like kinase 1	DEG_APCC_KENBOX_2	372:376	KKEND	APC,CDC20,FZR1	0.9873	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_APCC_KENBOX_2	1411:1415	KKEND	APC,CDC20,FZR1	0.9093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKEND

Degron related mutations and impact score

Drug responses associated with NUAK1 mutations

All proteins holding degron of KKEND