DegronMD - O60285(NUAK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R364Q	TCGA-30-1862	OV	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.R364Q	DO27988	OV	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.R364W	TCGA-44-A47F	LUAD	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.R364W	DO222864	COCA	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.R364W	DO24180	LUAD	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.S367L	TCGA-A6-5661	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1944
p.S367L	DO8634	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1944
p.S367L	SIDM01104	Melanoma	GDSC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1944
p.S367L	SK-MEL-31	skin	COSMIC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1944
p.R366W	TCGA-AA-A022	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1667
p.R366W	TCGA-FI-A2D0	UCEC	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1667
p.R366W	DO10647	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1667
p.R366W	DO43891	UCEC	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1667
p.S380A	TCGA-BR-8680	STAD	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.2222
p.S380A	DO47769	STAD	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.2222
p.E374Q	TCGA-BT-A3PH	BLCA	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation altering degron motif	0.6744
p.E374Q	DO856	BLCA	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation altering degron motif	0.6744
p.S380F	TCGA-CX-7086	HNSC	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.2222
p.S380F	DO15046	HNSC	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.2222
p.E363Q	TCGA-E7-A6MD	BLCA	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.0833
p.E363Q	DO219015	BLCA	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.0833
p.A384S	TCGA-HU-A4H0	STAD	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.A384S	DO47785	STAD	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1111
p.P386H	TCGA-IS-A3K7	SARC	TCGA	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.0556
p.P386H	DO220168	SARC	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.0556
p.P386T	DO229032	LICA	ICGC	KKEND	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.0556

Kaplan plot for NUAK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUAK1

UniProt ID: O60285

Entrez ID: 9891

Protein name: NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUAK1 in