DegronMD

Uniprot ID: P15408

Source protein: Fos-related antigen 2

Source gene: FOSL2

Class: DEG_SCF_FBW7_1

Location: 267:274

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 67.5625

COIL: 0.8341

CONS_SCORE: 0.6821

DSS_SCORE: 0.3799

HELIX: 0.015

FCONS_SCORE: 1.0366

RIG_SCORE: 0.7572

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E258Q	TCGA-95-7944	LUAD	TCGA	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.G257S	TCGA-D7-8574	STAD	TCGA	VTSTPAVT	DEG_SCF_FBW7_1	0.0556
p.S258C	DO228331	BRCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.G272R	DO227802	COCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.7568
p.S275L	DO218958	PAAD	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.3056
p.S278F	DO229459	SKCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.2222
p.S278F	DO37798	SKCM	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.2222
p.D277N	DO37519	SKCM	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.25
p.S271I	DO222387	STAD	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.7341
p.S260A	DO43041	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.1389
p.A264V	DO41235	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.25
p.R267I	DO42793	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	0.8102
p.G276D	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VTSTPAVT	DEG_SCF_FBW7_1	0.2778
p.G276D	NCI-H520	lung	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.2778
p.V267A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VTSTPAVT	DEG_SCF_FBW7_1	0.6936
p.V267A	ACH-000920	Leukemia	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.6936
p.V267A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.6936
p.V258M	ACH-000219	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	ACH-000934	Breast Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	ACH-000957	Colon/Colorectal Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	ACH-002001	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	ACH-002002	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	ACH-002003	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	A375	skin	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.V258M	LS-180	large_intestine	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.0833
p.G268D	ACH-000395	Lung Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.7198
p.G268D	NCI-H520	lung	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.7198
p.E281Q	ACH-000503	Head and Neck Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	0.1389
p.V259A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTPAVT

Degron related mutations and impact score

Drug responses associated with FOSL2 mutations

All proteins holding degron of VTSTPAVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SCF_FBW7_1	267:274	VTSTPAVT	FBXW7	0.9961	More...