DegronMD

Uniprot ID: Q7Z5P9

Source protein: Mucin-19

Source gene: MUC19

Class: DEG_SCF_FBW7_1

Location: 3163:3170

E3 ligase: FBXW7

DEGRON score: 0.9168

ASA_SCORE: 103.7375

COIL: 0.9194

CONS_SCORE: 0.3085

DSS_SCORE: 0.635

HELIX: 0.0133

FCONS_SCORE: 1

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3165P	DO45187	LIRI	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	0.7503
p.G3167R	DO222647	MELA	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	0.7568
p.T3159N	DO46342	OV	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	0.2222
p.T3156A	DO232761	PBCA	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	0.1389
p.V3175M	ACH-000030	Lung Cancer	CCLE	VTVTPRQS	DEG_SCF_FBW7_1	0.1944
p.G3180A	ACH-000867	Lung Cancer	CCLE	VTVTPRQS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5P9	Mucin-19	DEG_SCF_FBW7_1	3163:3170	VTVTPRQS	FBXW7	0.9168	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons