DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: LIG_APCC_ABBA_1

Location: 856:861

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 69.7

COIL: 0.875

CONS_SCORE: 0.3535

DSS_SCORE: 0.4338

HELIX: 0.0702

FCONS_SCORE: 1.0433

RIG_SCORE: 0.7803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W853C	DO8634	COAD	ICGC	FTPFID	LIG_APCC_ABBA_1	0.6944
p.S847Y	DO230313	COCA	ICGC	FTPFID	LIG_APCC_ABBA_1	0.0833
p.A852P	DO223665	LUAD	ICGC	FTPFID	LIG_APCC_ABBA_1	0.6667
p.F861C	DO41903	UCEC	ICGC	FTPFID	LIG_APCC_ABBA_1	0.7108
p.F861C	DO41799	UCEC	ICGC	FTPFID	LIG_APCC_ABBA_1	0.7108
p.Q870H	ACH-000994	Endometrial/Uterine Cancer	CCLE	FTPFID	LIG_APCC_ABBA_1	0.5278
p.S860P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.6752
p.A848V	LIM1215	large_intestine	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.1111
p.S861P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.6752
p.T869K	Ca9-22	upper_aerodigestive_tract	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.1111
p.A854V	LIM1215	large_intestine	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.7222
p.V867L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	LIG_APCC_ABBA_1	856:861	FTPFID	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons