DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: LIG_APCC_ABBA_1

Location: 815:820

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9806

ASA_SCORE: 74.7833

COIL: 0.5663

CONS_SCORE: 0.2782

DSS_SCORE: 0.6435

HELIX: 0.0677

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T809M	TCGA-D5-6541	COAD	TCGA	MIVHDD	LIG_APCC_ABBA_1	0.6111
p.T809M	TCGA-PG-A6IB	UCEC	TCGA	MIVHDD	LIG_APCC_ABBA_1	0.6111
p.E812K	DO518	BLCA	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.25
p.D822N	DO27652	LUSC	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.2778
p.R815C	DO227933	PBCA	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.8301
p.R815C	DO223286	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.8301
p.G821V	DO47100	RECA	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.3056
p.S821N	DO42280	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.3056
p.T819S	DO52419	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	0.7116
p.R812W	ACH-000950	Colon/Colorectal Cancer	CCLE	MIVHDD	LIG_APCC_ABBA_1	0.25
p.R812W	LoVo	large_intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	0.25
p.R815W	LoVo	large_intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	0.8634
p.V816L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MIVHDD	LIG_APCC_ABBA_1	0.6765
p.K809N	SNU-81	large_intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	LIG_APCC_ABBA_1	815:820	MIVHDD	APC,CDC20,FZR1	0.9806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons