DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: DEG_SCF_FBW7_2

Location: 825:832

E3 ligase: FBXW7

DEGRON score: 0.989

ASA_SCORE: 81.55

COIL: 0.8751

CONS_SCORE: 0.2651

DSS_SCORE: 0.628

HELIX: 0.0654

FCONS_SCORE: 0.9823

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L835I	TCGA-AP-A1DV	UCEC	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	0.25
p.P829Q	TCGA-D3-A1Q6	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	0.7035
p.T828A	TCGA-EE-A182	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	0.825
p.S842F	TCGA-GN-A4U4	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	0.5
p.L835F	DO228648	GACA	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.25
p.I837N	DO18938	KIRC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.1944
p.Y834C	DO26250	LUAD	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.7222
p.D822N	DO27652	LUSC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.25
p.G821V	DO47100	RECA	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.2222
p.E835K	DO48665	SKCM	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.25
p.S821N	DO42280	UCEC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	0.2222
p.G827S	SIDM00084	Glioblastoma	GDSC	PAMTPSKE	DEG_SCF_FBW7_2	0.6993
p.G827S	SF295	central_nervous_system	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.6993
p.E832V	HCT-116	large_intestine	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.7693
p.S841I	NCI-H1693	lung	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.0833
p.G826S	SF295	central_nervous_system	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.6993
p.V837I	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.1944
p.V833I	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.3056
p.E828V	HCT-116	large_intestine	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SCF_FBW7_2	825:832	PAMTPSKE	FBXW7	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons