DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: DEG_Kelch_Keap1_1

Location: 803:808

E3 ligase: KEAP1

DEGRON score: 0.9745

ASA_SCORE: 80.65

COIL: 0.8578

CONS_SCORE: 0.2819

DSS_SCORE: 0.6099

HELIX: 0.0845

FCONS_SCORE: 0.9001

RIG_SCORE: 0.5977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T809M	TCGA-D5-6541	COAD	TCGA	NLSNGE	DEG_Kelch_Keap1_1	0.75
p.T809M	TCGA-PG-A6IB	UCEC	TCGA	NLSNGE	DEG_Kelch_Keap1_1	0.75
p.L804F	TCGA-GM-A2DI	BRCA	TCGA	NLSNGE	DEG_Kelch_Keap1_1	0.587
p.E812K	DO518	BLCA	ICGC	NLSNGE	DEG_Kelch_Keap1_1	0.2222
p.W799C	DO229022	LICA	ICGC	NLSNGE	DEG_Kelch_Keap1_1	0.2222
p.R793C	DO38823	STAD	ICGC	NLSNGE	DEG_Kelch_Keap1_1	0.0556
p.I804R	DO41758	UCEC	ICGC	NLSNGE	DEG_Kelch_Keap1_1	0.8102
p.V807I	SIDM00985	Burkitt's Lymphoma	GDSC	NLSNGE	DEG_Kelch_Keap1_1	0.7076
p.V807I	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.7076
p.E802V	SIDM00783	Colorectal Carcinoma	GDSC	NLSNGE	DEG_Kelch_Keap1_1	0.3056
p.E802V	HCT-116	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.3056
p.M801L	ACH-000786	Lymphoma	CCLE	NLSNGE	DEG_Kelch_Keap1_1	0.7222
p.R812W	ACH-000950	Colon/Colorectal Cancer	CCLE	NLSNGE	DEG_Kelch_Keap1_1	0.2222
p.R812W	LoVo	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.2222
p.A797V	LIM1215	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.1667
p.V797E	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.1667
p.V794E	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.0833
p.R795C	NCI-H630	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.1111
p.V806I	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.7076
p.K809N	SNU-81	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.75
p.E801V	HCT-116	large_intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_Kelch_Keap1_1	803:808	NLSNGE	KEAP1	0.9745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons