DegronMD

Uniprot ID: Q9Y6W6

Source protein: Dual specificity protein phosphatase 10

Source gene: DUSP10

Class: DEG_SPOP_SBC_1

Location: 99:103

E3 ligase: SPOP

DEGRON score: 0.9358

ASA_SCORE: 73.7

COIL: 0.7896

CONS_SCORE: 0.2761

DSS_SCORE: 0.334

HELIX: 0.1376

FCONS_SCORE: 1.0203

RIG_SCORE: 0.7539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T110S	TCGA-49-4487	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1389
p.T110S	DO24780	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.A99S	TCGA-64-5781	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.7588
p.A99S	DO23740	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7588
p.G107A	TCGA-99-8032	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.G107A	DO23765	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.Q93K	TCGA-BF-A1PZ	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1667
p.Q93K	DO50279	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.G107R	TCGA-SJ-A6ZI	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2222
p.G107R	DO219784	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.R100Q	DO222884	COCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7329
p.K94I	DO234403	ESAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.K94T	DO48298	ESCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A92D	DO229022	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.A92V	DO24389	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.A92P	DO25010	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.M110L	DO36451	READ	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.N108T	DO41578	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A99T	SIDM00596	Endometrial Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A99T	ACH-000941	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A99T	ACH-000954	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A99T	ACH-001517	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A99T	HEC-1	endometrium	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.7139
p.G100D	SIDM00150	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.6087
p.G100D	ACH-000969	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.6087
p.G100D	KM12	large_intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons