DegronMD - Q9Y6W6(DUSP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T110S	TCGA-49-4487	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.T110S	DO24780	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.A99S	TCGA-64-5781	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7588
p.A99S	DO23740	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7588
p.G107A	TCGA-99-8032	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.G107A	DO23765	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.Q93K	TCGA-BF-A1PZ	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.Q93K	DO50279	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.G107R	TCGA-SJ-A6ZI	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.G107R	DO219784	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.R100Q	DO222884	COCA	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7329
p.K94I	DO234403	ESAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.K94T	DO48298	ESCA	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.A92D	DO229022	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.A92V	DO24389	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.A92P	DO25010	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.M110L	DO36451	READ	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.N108T	DO41578	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.A99T	SIDM00596	Endometrial Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.A99T	ACH-000941	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.A99T	ACH-000954	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.A99T	ACH-001517	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.A99T	HEC-1	endometrium	COSMIC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.G100D	SIDM00150	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6087
p.G100D	ACH-000969	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6087
p.G100D	KM12	large intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6087

Kaplan plot for DUSP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP10

UniProt ID: Q9Y6W6

Entrez ID: 11221

Protein name: Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP10 in