DegronMD

Uniprot ID: O43247

Source protein: Testis-expressed protein 33

Source gene: TEX33

Class: DEG_SPOP_SBC_1

Location: 7:11

E3 ligase: SPOP

DEGRON score: 0.7629

ASA_SCORE: 61.72

COIL: 0.6936

CONS_SCORE: 0.4459

DSS_SCORE: 0.5905

HELIX: 0.0464

FCONS_SCORE: 0.9807

RIG_SCORE: 0.6796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K20N	DO228008	LAML	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.T9A	DO220843	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A7E	DO36386	READ	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7701
p.L3P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AGTTT	DEG_SPOP_SBC_1	0.3333
p.L3P	ACH-001669	Leukemia	CCLE	AGTTT	DEG_SPOP_SBC_1	0.3333
p.L3P	ACH-002238	Leukemia	CCLE	AGTTT	DEG_SPOP_SBC_1	0.3333
p.L3P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.3333
p.A11V	CCK-81	large_intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons