DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SCF_FBW7_1

Location: 906:912

E3 ligase: FBXW7

DEGRON score: 0.7661

ASA_SCORE: 84.3

COIL: 0.7856

CONS_SCORE: 0.5347

DSS_SCORE: 0.2626

HELIX: 0.0176

FCONS_SCORE: 1.1809

RIG_SCORE: 0.8058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G896R	TCGA-86-A4JF	LUAD	TCGA	LATPITT	DEG_SCF_FBW7_1	0.0556
p.G896R	TCGA-IB-7651	PAAD	TCGA	LATPITT	DEG_SCF_FBW7_1	0.0556
p.G896R	DO45317	LUAD	ICGC	LATPITT	DEG_SCF_FBW7_1	0.0556
p.G896R	DO46657	PAAD	ICGC	LATPITT	DEG_SCF_FBW7_1	0.0556
p.A897V	TCGA-AJ-A3BG	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	0.0833
p.A897V	DO42633	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	0.0833
p.G914D	TCGA-BG-A222	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	0.2778
p.G914D	DO42977	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	0.2778
p.T908M	TCGA-CD-A4MG	STAD	TCGA	LATPITT	DEG_SCF_FBW7_1	0.7423
p.T908M	TCGA-CK-5916	COAD	TCGA	LATPITT	DEG_SCF_FBW7_1	0.7423
p.T908M	TCGA-PG-A6IB	UCEC	TCGA	LATPITT	DEG_SCF_FBW7_1	0.7423
p.T908M	DO8786	COAD	ICGC	LATPITT	DEG_SCF_FBW7_1	0.7423
p.T908M	DO48009	STAD	ICGC	LATPITT	DEG_SCF_FBW7_1	0.7423
p.T908M	DO52419	UCEC	ICGC	LATPITT	DEG_SCF_FBW7_1	0.7423
p.S905F	TCGA-D3-A8GI	SKCM	TCGA	LATPITT	DEG_SCF_FBW7_1	0.3056
p.S905F	DO50284	SKCM	ICGC	LATPITT	DEG_SCF_FBW7_1	0.3056
p.A897E	DO229008	LICA	ICGC	LATPITT	DEG_SCF_FBW7_1	0.0833
p.G896W	DO229259	THCA	ICGC	LATPITT	DEG_SCF_FBW7_1	0.0556
p.P909L	ACH-000269	Brain Cancer	CCLE	LATPITT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_SCF_FBW7_1	906:912	LATPITT	FBXW7	0.7661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons