DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_COP1_1

Location: 470:477

E3 ligase: COP1

DEGRON score: 0.9765

ASA_SCORE: 85.3375

COIL: 0.8956

CONS_SCORE: 0.4389

DSS_SCORE: 0.4346

HELIX: 0.022

FCONS_SCORE: 0.9822

RIG_SCORE: 0.7118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R479S	TCGA-55-7576	LUAD	TCGA	SSISVPTA	DEG_COP1_1	0.2778
p.R479S	DO24431	LUAD	ICGC	SSISVPTA	DEG_COP1_1	0.2778
p.T476A	TCGA-BG-A222	UCEC	TCGA	SSISVPTA	DEG_COP1_1	0.7139
p.T476A	DO42977	UCEC	ICGC	SSISVPTA	DEG_COP1_1	0.7139
p.S473F	TCGA-D9-A6EC	SKCM	TCGA	SSISVPTA	DEG_COP1_1	0.6871
p.S473F	DO50291	SKCM	ICGC	SSISVPTA	DEG_COP1_1	0.6871
p.A477T	TCGA-DF-A2KV	UCEC	TCGA	SSISVPTA	DEG_COP1_1	0.7139
p.A477T	DO219771	UCEC	ICGC	SSISVPTA	DEG_COP1_1	0.7139
p.A478D	DO229037	LICA	ICGC	SSISVPTA	DEG_COP1_1	0.3056
p.T460A	DO231051	LUSC	ICGC	SSISVPTA	DEG_COP1_1	0.0556
p.P475S	DO229221	THCA	ICGC	SSISVPTA	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_COP1_1	470:477	SSISVPTA	COP1	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons